Development of semi-artificial sensors and catalysts

Colorimetic and fluorometric probes are tremendously useful tools for detecting, imaging and tracking analytes in water, foods and biological media. Nevertheless, for many important applications “smart” molecular probes are still lacking.

My group develops metal-complexes and modified cofactors as receptors, chemosensors and reaction-based probes for detecting biologically important analytes in competitive media.[1,2]

Our research has attracted international attention and has been highlighted several times in ChemistryWorld as well as several printed (e.g. Die Welt, WAZ) and online media. A test for toxic cyanide detection has been developed in my group and is commercialized as CyanoKitTM by the spin-off company CyanoGuard AG.[3]

The technology was awarded in 2016 with the second prize at the Emerging Technologies Competition in the category food and water by the Royal Society of Chemistry. Moreover, my group developed an unprecedented method for visualizing endogenous pyrophos-phate in mitochondria.[2,4]

Fundamental investigations on structure-reactivity relationships accompany all of our studies and are used for implementing improve-ments into current systems and for developing new probes for other target analytes with unprecedented sensitivity and selectivity.[5,6]

F. Zelder, Chem. Commun., 2015, 51, 14004.

Detecting biologically relevant phosphates with locked salicylaldehyde probes in water
N. Kumari, F. Zelder, Chem. Commun., 2015, 51(96), 17170.

C. Mannel-Croise and F. Zelder, ACS Appl Mater Inter, 2012, 4, 725.

N. Kumari, H. Y. Huang, H. Chao, G. Gasser and F. Zelder, ChemBioChem, 2016, 17, 1211.

C. Männel-Croisé and F. Zelder, Inorg. Chem., 2009, 48, 1272.

C. Männel-Croisé, B. Probst and F. Zelder, Anal. Chem., 2009, 81, 9493.