New Antibiotics and Anti-cancer Drugs
Cancer and bacterial infections represent a big threat to modern society. Considering the significant rise of resistance to common antibiotic treatments, drugs with a new mode-of-action are urgently required.

My laboratory develops antivitamin derivatives and bioconjugates as therapeutic agents.

Selected papers:

[1] Recent trends in the development of vitamin B12 derivatives for medicinal applications
F. Zelder, Chem. Commun., 2015, 51, 14004.

Coordination chemistry and biological activity of 5′-OH modified quinoline–B12 derivatives
K. Zelenka, H. Brandl, B. Spingler, F. Zelder, Dalton Trans., 2011, 40, 9665.

Vitamin B12 Mimics Having a Peptide Backbone and Tuneable Coordination and Redox Properties
K. Zhou and F. Zelder, Angew. Chem. Int. Ed., 2010, 49, 5178.


Sensing Important Analytes
Colorimetic and fluorometric probes are tremendously useful tools for detecting, imaging and tracking analytes in water, foods and biological media.

My group develops metal-complexes and modified cofactors as receptors, chemosensors and reaction-based probes for detecting biologically important analytes in competitive media

Selected papers:

[1] Detecting biologically relevant phosphates with locked salicylaldehyde probes in water
N. Kumari, F. Zelder, Chem. Commun., 2015, 51, 17170.

[2] Complex Samples Cyanide Detection with Immobilized Corrinoids
C. Mannel-Croise and F. Zelder, ACS Appl Mater Inter, 2012, 4, 725.

[3] Side chains of cobalt corrinoids control the sensitivity and selectivity in the colorimetric detection of cyanide
C. Männel-Croisé and F. Zelder, Inorg. Chem., 2009, 48, 1272.


New semi-artificial catalysts
Understanding enzymatic reactivity on the molecular level is crucial for the future development of efficient green catalysts for difficult organic reactions such as C-H activation or CO2  reduction.

My laboratory mimics structure and function of cofactor-protein complexes with (semi-)artificial metal complexes.

Selected papers:

[1] ​​ Immobilised vitamin B12 as a biomimetic model for base-off/histidine-on coordination
C. Männel-Croisé, F. Zelder, Chem. Commun., 2011, 47, 11249.

[2] Modulating the cobalt redox potential through imidazole hydrogen bonding interactions in a supramolecular biomimetic protein-cofactor model
M. Sonnay, T. Fox, O. Blacque, F. Zelder, Chem. Sci., 2016, 7, 3836.